 Resonant Aegis | Single-target buff | invulnerable, 2s + 0.5s × (rank − 1) |
 Rest | Single-target buff | +1 speed, +2% hp/s, +2% mana/s, −2% rage/s |
 Resurrection | Single-target heal | resurrect player (60% max hp, mana = 20% max hp, +75% lost XP) or mercenary (10% max hp) |
 Resurrection Effects | Single-target buff | grants invis, even vs see invis, 10s |
 Root | Area debuff | root, melee hits on the target heal the attacker 3% + 1% × (rank − 1) of dmg, 15s + 5s × (rank − 1) |
 Rot of the Plaguebringer | Single-target debuff | root, 120 disease dmg/s, 12s |
 Rotting Infestation | Single-target debuff | 15 disease dmg/s, 30s |
 Rotting Touch | Area debuff | −15% − 0.5% × (rank − 1) haste, 80 + 8 × (rank − 1) disease dmg/s, 12s |
 Ruinforge | Area damage | attack power + 1 500 physical dmg, 100% lifetap, 100% chance a random equipped item loses 1 - 4 durability, 100% stun (1s) |
 Ruinous Flameburst | Area damage | spell power + 3 000 fire dmg, 100% lifetap, 100% chance a random equipped item loses 1 - 4 durability, 100% stun (1s) |
 Rune Ward | Single-target buff | +1 500 ward, 5m |
 Runebound Aegis | Single-target buff | invulnerable, 3.15s + 0.15s × (rank − 1) |
 Runeshield | Single-target buff | invulnerable, 2s + 0.5s × (rank − 1) |
 Rupture | Single-target debuff | −25 × rank AC (−50% of STR), 30s |
 Sabretooth Meat I | Single-target buff | +50 max mana, +2% accuracy, 30m |
 Sabretooth Meat II | Single-target buff | +50 max mana, +3% accuracy, 30m |
 Sabretooth Meat III | Single-target buff | +50 max mana, +4% accuracy, 30m |
 Sabretooth Meat IV | Single-target buff | +50 max mana, +8% accuracy, 30m |
 Sanctuary of Renewal | Area heal | heals itself & every monster within 12 yd, 5 000 hp |
 Sanctum Collapse | Area effect | 5 000 physical dmg, 100% stun (2s), 12 random zones + 1 on target, 2 yd wide |
