 Slow | Single-target debuff | −8% × rank haste, 1m |
 Smite | Single-target projectile | spell power + 12 × rank magic dmg |
 Smoldering Wrath | Single-target debuff | 800 fire dmg/s, 60% Cleanse Resist, 30s |
 Snake Attack | Single-target damage | attack power + 5 physical dmg, 0.9% stun (1s) |
 Song of Varensea | Area debuff | Bard song, sleep, 15s |
 Soul Draught | Single-target damage | spell power + 6 500 magic dmg, 30% lifetap |
 Soul Reaping | Single-target damage | (spell power + 90 + 20 × (rank − 1)) × 150% cold dmg, 30% lifetap |
| Soulpiercing | Single-target damage | spell power + 1 800 magic dmg, 35% lifetap |
 Soulreaver Attack | Single-target damage | attack power + 10 000 physical dmg, 100% lifetap |
 Spectral Blast | Single-target projectile | spell power + 60 magic dmg |
 Spectral Drain | Single-target debuff | −2 speed, 35 magic dmg/s, 30s |
 Spellrend | Single-target debuff | −20 × rank magic res (−40% of INT), 1m |
 Spellshatter | Single-target debuff | −5 × rank magic res (−40% of mercenary INT), 5m |
 Spellwind | Area buff | +15% spell casting haste, not Warriors or Rogues, 5m |
 Sphere of Hate | Area damage | spell power + 55 000 magic dmg, 25% stun (1.5s) |
 Spicy Forest Slapper | Single-target buff | +20 spell power, 1m |
 Spider Attack | Single-target damage | attack power + 5 physical dmg, 0.9% stun (1s) |
 Spider Bite | Single-target damage | spell power + 150 poison dmg, 100% stun (1s) |
 Spider Touch | Single-target damage | spell power + 300 poison dmg |
 Spirit of Bear | Area buff | +60 × rank max hp (+2 per WIS), 30m |
